Manufacturing equipmentManufacturing equipment

Manufacturing equipment

 We offer the Safe, Stable, Low-cost, and High-quality APIs and intermediates at our cGMP-compliant multipurpose plants. We supply APIs and intermediates under Quality assurance to all steps such as raw material procurement, manufacturing, processing, and shipping.

Yoshitomi Plant details

Commercial production facility

Reaction/
technology
Dangerous reactions
Tetrazolization diazotization nitration hydrogen
reduction
Grignard
reaction
Others
Amination alkylation imidization iminoethylation ethylation
esterification carbamoylation sulfonation dehalogenation thioamination
disulfidization nitrosylation Friedel–Crafts
reaction
Sandmeyer
reaction
hydroboration
halogenation hydrazine condensation methylolation salt
synthesis
hydrolysis reduction
synthesis
optical
separation
acid amination acid chloride
decarboxylation Kolbe–Schmitt
reaction, etc.
     
Substances
(examples)
Water-reactive reagents: n-BuLi, sec-BuLi, 60% NaH, etc.
Fire Services Act Class 5 Dangerous Goods: Organic peroxides, NaN3, hydroxylamine hydrochloride, etc.
Other: Phosphorus pentasulfide, inorganic CN compounds, diborane, bromine, etc.
Equipment Reactor 0.5–20 m3 GL, Stainless steel, HC equivalent
Anchor blade, Three-blade retreat impeller, Highly-efficient multifunctional mixing impeller, etc.
Filter
(Centrifuge)
24–48 inches Stainless steel, HC equivalent, Teflon lining vertical centrifuge (upper exhaust and lower exhaust types)
Drying equipment 1–7 m3 Conical dryer, vacuum desiccators with trays
GL, Stainless steel
Mills 16 Pin mill, cutter mill, hammer mill, jet mill, etc.
Clean room 9 Maintained at Class 100,000
Temperature Range –80 to 180℃ UTT: liquid nitrogen, brine, chilling water, steam (190℃)
Operating pressure FV approx. 0.99 Mpa  

IMP facility

Reaction/
technology
Same as that of commercial facilities and as per clients’ requests
Substances As per clients requests
Equipment Reactor 100–8000 L GL: Total 50 m3
Stainless steel: Total 30 m3
Anchor blade, Three-blade retreat impeller, Highly-efficient multifunctional mixing impeller, Molepaw blade, etc.
Filter
(Centrifuge)
24–42 inches Stainless steel, HC equivalent
Drying
equipment
200–850 L GL
Mills 4 Pin mill, cutter mill, hammer mill, jet mill
Clean room 1 Maintained at Class 100,000
Temperature Range –80 to 180℃ UTT: Liquid nitrogen, brine, chilling water, steam (190℃)
Operating pressure FV approx. 0.97 MPa