Synthesis TechnologySynthesis Technology

Organic Synthesis  
We leverage our competitive advantage of various organic synthesis technologies so as to propose the best solutions by utilizing our manufacturing routes that can be optimized to meet the needs of individual customers.



○ Azidation Tetrazole synthesis
Curtius rearrangement
○ Asymmetric synthesis Asymmetric reduction
by homogeneous catalysts
○ Cyanation  
○ Oxidation Hydrogen Peroxide
○ Reduction Metal hydrides
Raney-Ni
○ Optical resolution  
○ Organometallic reaction Organic tin compounds
Grignard reaction
○ Special reagent Liquid ammonia, P2S5
○ Others formylation, sulfonation,
esterification, isocyanation,
diazotization,
reductive amination
Cryogenic reaction

Lowest temperature -80 deg. C
Dedicated tank for n-BuLi
Large-scale reactors; 3,000 and 5,000 L

Cryogenic reaction

Capable of offering the best solutions for early stages to commercial production

Biosynthesis

Since we succeeded in the world’s first industrialization of asymmetric reduction of ketone by the enzymatic method in 1995, our biotechnologies have been utilized in various processes, as represented by the production of optically active alcohol. Our library has a variety of strains and enzymes, and allows us to propose highly selective and cost-competitive processes for diversified matrices.

Synthesis of optically active alcohol by asymmetric reduction
Synthesis of optically active alcohol by asymmetric reduction
Synthesis of optically active carboxylic acid and alcohol by asymmetric hydrolysis
Synthesis of optically active carboxylic acid and alcohol by asymmetric hydrolysis
Synthesis of non-natural glucose by fermentation
Synthesis of non-natural glucose by fermentation
Articles

Asymmetric synthesis of b-hydroxy-a-amino acid via dynamic kinetic resolution using biocatalysis
Kazuya Okano, Mari Hara Yasuda
Speciality Chemicals Magazine 2007, 27(2), 48-50.

Asymmetric reduction of aliphatic ketones by biocatalysis
Kazuya Okano, Yasumasa Dekishima
Speciality Chemicals Magazine 2006, 26(9), 18-19.

Synthesis & application of chiral hydrobenzoin.
Kazuya Okano, Takao Ikariya,
Speciality Chemicals Magazine 2006, 26(3), 34-37.

Production of D-threitol by biocatalytic stereoinversion
Kazuya Okano, Mari Yasuda
Chimica Oggi/Chemistry Today 2005, 23(5),

L-ribose, a new chiral block for L-nucleoside analogs.
Kazuya Okano, Makoto Ueda
Speciality Chemicals Magazine 2005, 25(3), 30-32.

Asymmetric reduction using biocatalytic reactions.
Kazuya Okano, Makoto Ueda
Speciality Chemicals Magazine 2004, 24(11), 40-41